SAN FRANCISCO -- The Carolina Panthers can now say they have that signature win everybody has been waiting to see: on the road, against the reigning NFC champions, in November. Black Friday Nike Air Max 97 . While facing one of the NFLs brightest young quarterbacks, to boot. Carolinas swarming, opportunistic defence stopped Colin Kaepernick in his tracks. Drayton Florence intercepted a pass by Kaepernick in the final minute to seal a 10-9 victory Sunday to snap the San Francisco 49ers five-game winning streak and give the Panthers their fifth straight win. So much for the idea that Carolina hadnt beaten any team of consequence thus far. "I dont think it really bothers us, it gives us the opportunity to step up to the challenge. We did," said wide receiver Steve Smith, who had six receptions. "A win like this can boost us, a win like this can continue to give us life throughout the season, and make us feel like were working for something, and we are." Graham Gano kicked a 53-yard field goal with 10:05 remaining that held up as the Panthers (6-3) twice shut down Kaepernick on last-ditch drives with swarming defence. DeAngelo Williams broke two tackles for a 27-yard touchdown run late in the first half that pulled Carolina within 9-7. Gano missed wide left on a 48-yard field goal in the third period, but came through later. San Francisco (6-3) got the ball back with 5:25 left at its 1, then again with 1:02 to go. Phil Dawson kicked a season-best 52-yard field goal among his three for the 49ers, who lost tight end Vernon Davis and rookie safety Eric Reid to concussions. Carolina fumbled twice in the closing moments, but recovered each time. First, Jonathan Stewart fumbled and Mike Tolbert pounced on the ball. Cam Newton recovered his own bobble. This was hardly the highly touted showdown between 2011 No. 1 overall pick Newton and Kaepernick, the sixth quarterback drafted that year, in the second round. They roomed together during the scouting combine. For Newton, the numbers hardly mattered. "This game is a maturity jump for us, because in the past what Ive been a part of, weve been somewhat uncertain of how we will turn out in these types of games," Newton said. "We needed that type of game, just to be in a dog fight, in somewhat of a barnburner, to show what type of team this really is." Kaepernick went 11 for 22 for 91 yards with an interception and was sacked six times for a 42.0 passer rating. Newton was only slightly better, going 16 of 32 for 169 yards, an interception and four sacks for a 52.7 rating. For two teams that have been putting up points at a prolific pace for the past month, the defences dictated this one. "As the game went on, it got more and more intense," Smith said. More than losing the game, the 49ers losses of Davis and Reid could be troublesome for the reigning NFC champions as they hit the road next week for New Orleans, then go to Washington. "Well do what we do, bounce back, regroup, refit and reorganize and come back this week," coach Jim Harbaugh said. Davis didnt return after sustaining a concussion in the second quarter, then Reid went down on a helmet-to-helmet hit on Mike Tolbert in the third. Earlier, Reid recovered a fumble to give him five takeaways in an already-stellar rookie season that also includes three interceptions. Frank Gore had 16 carries for 82 yards, accounting for most of San Franciscos 151 total yards. "For the most part, I dont really think they did anything that necessarily confused us," 49ers centre Jonathan Goodwin said. "They only gave up nine points. Its hard not to give them credit. We expected it to be a physical game. Did we expect to only score nine points? Nah." Dawson put San Francisco ahead on a 52-yard field goal on the teams opening drive, then kicked second-quarter field goals of 43 and 25 yards. But Kaepernick could never get his team in the end zone in its first game since a bye on the heels of a win over Jacksonville in London. 49ers pass-rushing specialist and 2012 All-Pro linebacker Aldon Smith played limited snaps after missing five games to undergo treatment for substance abuse. Wide receiver Mario Manningham started and had three catches in his season debut, nearly 11 months after a serious left knee injury that required surgery. Carolina got going after managing only minus-7 yards passing and 12 total yards in the first quarter. The Panthers finished with 250 total yards. "This one really did come down to the way the defence played," Panthers coach Ron Rivera said. "Any time you put yourself in a position where you can force the other team to kick field goals, you get a chance to win." Notes: The 49ers also lost TE Garrett Celek to a hamstring injury in the first quarter, while DT Ray McDonald hurt an ankle. ... Panthers LB Chase Blackburn did not return in the second half because of a foot injury. Clearance Nike Air Max 97 .ca. In addition to the game being aired in its entirety on CTV Two Vancouver Island and TSN.ca, TSN2 will also have coverage of Whitecaps FC immediately following NASCAR Sprint Cup Series: Toyota Owners 400. Wholesale Nike Air Max 97 . They signed their first kicker. Ottawa inked Nick Setta, a 32-year-old native of Lockport, Illinois, to a contract. https://www.fakeairmax97wholesale.com/ .A. Happ? Happs seven wins are second on the staff to Mark Buehrles 10. Win-loss record is an antiquated stat, sure, but win total is generally an indication of a pitchers ability to work deep into games, enough to be personally affected by the result.MILWAUKEE - Neil Walker hit a three-run homer, Charlie Morton pitched seven strong innings and the Pittsburgh Pirates beat Milwaukee 5-2 Monday to retake the NL Central lead. The Pirates moved one game of St. Louis, which lost earlier in the day at Cincinnati. Pittsburgh won the opener of a nine-game road trip. Walker broke it open with his homer in the seventh for a 5-1 lead. Jose Tabata added three hits, including a pair of run-scoring singles. Morton (7-3) gave up seven hits and one earned run. He walked two and struck out six while winning his fourth straight decision. Mark Melancon pitched the ninth for his 10th save in 12 chances. Tyler Thornburg (1-1) allowed two runs and six hits in six innings. The Brewers opened the scoring in the second when Juan Francisco sliced a double that landed just inside the left field line. Francisco scored on a single by Logan Schafer. The Pirates tied it in the third when Clint Barmes led off with a single and later scored on a single by Tabata. Milwaukee threatened in the third when Norichika Aoki tried to score on Jonathan Lucroys one-out grounder to third. Aoki was tagged out in a rundown by third baseman Pedro Alvarezz, who then threw out Lucroy as he attempted to advance to second. Discount Nike Air Max 97. The Brewers loaded the bases with two outs in the fourth but Thornburg struck out swinging. Barmes led off with a double in the fifth and Tabata singled home the go-ahead run. Thornburg struck out Marlon Byrd with the bases loaded to prevent further damage. Singles by Morton and Tabata set up Walkers 10th home run. The Brewers added a run in the seventh when a soft throw from the outfield skipped under Alvarezs glove for an error and rolled into the Pirates dugout, allowing Aoki to score from second base. NOTES: The victory gave the Pirates three consecutive wins in Milwaukee for the first time since 2004. ... Milwaukees Jean Segura stole his league-leading 39th base in the fifth. ... Brewers relief pitcher Tom Gorzelanny left the game with tightness in his left shoulder after throwing just two pitches. ... Michael Blazek, acquired by Milwaukee on Sunday from St. Louis as the player to be named in a deal that sent relief pitcher John Axford to the Cardinals, pitched a scoreless inning of relief. ... Thornburg made his fourth start of the season and first since Aug. 14. ' ' '